Many advertisers — even large national ones — seem to be completely unaware of the environments in which they place their advertising. I don’t mean that in terms of the desired audience; rather, it’s in creating ads that will work with the audience and environment.
Case in point was Greatcall, the national advertiser offering a medical response system (ala “I’ve fallen and I can’t get up”). I found their ad on the back cover of the large-print edition of Reader’s Digest magazine. Given the demographics of the magazine — especially in its large-print version — the audience is well worth the extra money this company has shelled out.